Mohd-Sarip, Adone ; Cléard, Fabienne ; Mishra, Rakesh K. ; Karch, François ; Peter Verrijzer, C. (2005) Synergistic recognition of an epigenetic DNA element by Pleiohomeotic and a Polycomb core complex Genes & Development, 19 . pp. 1755-1760. ISSN 0890-9369
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Official URL: http://genesdev.cshlp.org/content/19/15/1755.short
Related URL: http://dx.doi.org/10.1101/gad.347005
Abstract
Polycomb response elements (PREs) are cis-acting DNA elements that mediate epigenetic gene silencing by Polycomb group (PcG) proteins. Here, we report that Pleiohomeotic (PHO) and a multiprotein Polycomb core complex (PCC) bind highly cooperatively to PREs. We identified a conserved sequence motif, named PCC-binding element (PBE), which is required for PcG silencing in vivo. PHO sites and PBEs function as an integrated DNA platform for the synergistic assembly of a repressive PHO/PCC complex. We termed this nucleoprotein complex silenceosome to reflect that the molecular principles underpinning its assemblage are surprisingly similar to those that make an enhanceosome.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Cold Spring Harbor Laboratory Press. |
| Keywords: | Polycomb; Pleiohomeotic; PRE; Epigenetic Silencing; Silenceosome |
| ID Code: | 79974 |
| Deposited On: | 30 Jan 2012 05:50 |
| Last Modified: | 30 Jan 2012 05:50 |
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