Mukherjee, Koushik ; Bhattacharyya, Jayanta ; Sen, Joyeeta ; Sistla, Ramakrishna ; Chaudhuri, Arabinda (2008) Covalent grafting of common trihydroxymethylaminomethane in the headgroup region imparts high serum compatibility and mouse lung transfection property to cationic amphiphile Journal of Medicinal Chemistry, 51 (6). pp. 1967-1971. ISSN 0022-2623
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Official URL: http://pubs.acs.org/doi/abs/10.1021/jm070879u
Related URL: http://dx.doi.org/10.1021/jm070879u
Abstract
Clinical success of cationic transfection lipids in nonviral gene therapy continues to remain critically dependent on the use of serum compatible cationic amphiphiles efficient in delivering genes into our body cells. To this end, we demonstrate that covalent grafting of simple Tris-base component of the widely used biological Tris buffer in the headgroup region is capable of imparting high serum compatibility and intravenous mouse lung transfection properties to cationic amphiphile.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 7989 |
| Deposited On: | 25 Oct 2010 09:36 |
| Last Modified: | 31 Jan 2011 08:09 |
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