Affinity cantilever sensors for cardiac diagnostics

Joshi, Manoj ; Kale, Nitin ; Mukherji, S. ; Lal, R. ; Ramgopal Rao, V. (2007) Affinity cantilever sensors for cardiac diagnostics Indian Journal of Pure & Applied Physics, 45 . pp. 287-293. ISSN 0019-5596

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Cardiac problems are on the rise in the Indian sub-continent due to the changing-life styles and food habits. Acute Myocardial Infraction (AMI) is becoming a major concern. In this paper, we report the development of affinity cantilever based sensors for the detection of AMI with optical and electrical readouts. We designed, simulated and fabricated these cantilevers with various micro fabricated materials such as silicon dioxide, silicon nitride and SU-8. Thin films such as silicon nitride and p-type polysilicon are deposited using hot wire CVD technique. For electrical detection, p-type polysilicon was used as a piezoresistive layer. The mechanical and electrical performance parameters of these cantilevers were investigated using Atomic Force Microscope (AFM) set-up. The top surface of these cantilevers was selectively immobilized with the antibodies. Following this, antibody specific antigens were allowed to react with the cantilever surface in the liquid cell of AFM set-up for the optical detection. For electrical signal detection, microcontroller based signal conditioning and digital readout circuit was developed.

Item Type:Article
Source:Copyright of this article belongs to National Institute of Science Communication and Information Resources.
Keywords:Cantilever Sensors; Cardiac Diagnostics; Myocardial Infraction; Piezoresistive Layer; Atomic Force Microscope
ID Code:79712
Deposited On:28 Jan 2012 11:52
Last Modified:18 May 2016 21:59

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