Theoretical studies on α- helix - DNA interactions

Gopalakrishnan, B. ; Bansal, M. (1988) Theoretical studies on α- helix - DNA interactions Journal of Biomolecular Structure & Dynamics, 5 (4). pp. 859-871. ISSN 0739-1102

Full text not available from this repository.


The interaction energies between (Ala)10 and alpha-helix fragment and different nucleotide sequences in right-handed B-form have been optimized using semi-empirical potential energy functions. The energies are calculated for two different orientations of the alpha-helix, viz., when the alpha-helix axis taken in the N---C direction is (i) parallel and (ii) antiparallel to the 5'-3- ascending strand of DNA, proximal to it. When both the DNA molecule as well as the alpha-helix are treated as rigid molecules it is found that a polyalanine alpha-helix has slightly more favourable contacts when it is in the proximity of a four nucleotide sequence of 5'-(N-A-T-N)-3' type, where N is either a purine or a pyrimidine. However, when the two interacting molecules are allowed to undergo local structural variations then the interaction energy appears to be independent of the base sequence confirming the non-specific nature of these interactions.

Item Type:Article
Source:Copyright of this article belongs to Adenine Press.
ID Code:79555
Deposited On:27 Jan 2012 13:06
Last Modified:27 Jan 2012 13:06

Repository Staff Only: item control page