Tailor-made therapy in rheumatoid arthritis: fact or fiction?

Haroon, Nigil ; Misra, Ramnath ; Aggarwal, Amita (2008) Tailor-made therapy in rheumatoid arthritis: fact or fiction? The Israel Medical Association Journal, 10 . pp. 139-141. ISSN 1565-1088

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Official URL: http://www.ima.org.il/imaj/ar08feb-11.pdf


There has been a paradigm shift in the treatment of rheumatoid arthritis in recent years. Early and aggressive treatment with good control of disease activity has improved the prognosis of the disease, however, there is significant variability in the response of patients to different therapeutic agents. Hence it is essential to find the predictors of response to a drug at baseline so that we can avoid the delay in achieving remission and improve the outcome. Here we review the literature on available predictors for treatment response in general and specifically for methotrexate and biological agents. We also look at specific scores or indices that can help predict the response in individual patients.

Item Type:Article
Source:Copyright of this article belongs to Israel Medical Association.
Keywords:Rheumatoid Arthritis; Pharmacogenomics; Cytokine Suppression; Efficacy; Methotrexate; Infliximab
ID Code:79527
Deposited On:27 Jan 2012 14:26
Last Modified:27 Jan 2012 14:26

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