Methotrexate induced accelerated nodulosis

Agarwal, V. ; Aggarwal, Amita ; Misra, R. (2004) Methotrexate induced accelerated nodulosis Journal of the Association of Physicians of India, 52 . pp. 538-540. ISSN 0004-5772

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Methotrexate induced accelerated nodulosis (MIAN) is a rare but unique side effect of methotrexate therapy. There is paucity of data from our country about this entity. We analyzed 14 cases of MIAN and studied its association with gender, rheumatoid factor positivity and dose and duration of methotrexate. Fourteen patients (8 females), 12 with rheumatoid arthritis (8 seropositive), one each with juvenile idiopathic (JIA) and psoriatic arthritis (PsA) were detected to have MIAN during study period. All the patients presented with acute onset of multiple nodules. Radial border of fingers was the most commonly involved site. Disease was inactive in all but two patients at the time of appearance of MIAN. There was no association of MIAN with gender, rheumatoid factor positivity, disease duration, cumulative dose and duration of methotrexate therapy. Two patients each were treated with colchicine, D-penicillamine or hydroxy-chloroquine for 3-6 months without any response. We conclude that MIAN is a benign side effect of methotrexate treatment.

Item Type:Article
Source:Copyright of this article belongs to Association of Physicians of India.
ID Code:79504
Deposited On:27 Jan 2012 13:19
Last Modified:18 May 2016 21:51

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