Primary Sjogren's syndrome : rarity in India

Misra, R. ; Hissaria, P. ; Tandon, Vini ; Aggarwal, Amita ; Krishnani, N. ; Dabadghao, S. (2003) Primary Sjogren's syndrome : rarity in India Journal of the Association of Physicians of India, 51 . pp. 859-862. ISSN 0004-5772

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Objective : Primary Sjogren's syndrome (SS) is rarely reported from India. We have studied the clinical spectrum and immunological profile of patients with primary SS. Methods : A prospective analysis of patients with primary Sjogren's syndrome fulfilling San Francisco criteria, seen at our clinic in the last 10 years was carried out. Results : The study included 26 patients, 21 being women. The presenting symptoms included dry eyes, dry mouth, and arthritis/ arthralgia. Extra-glandular manifestations were glomerulonephritis, vasculitis, renal tubular acidosis and peripheral neuropathy. The important laboratory abnormalities were hypergammaglobulinaemia (16/20), antinuclear antibodies (18/26), anti-La (11/19) and anti-Ro (10/19). Minor salivary gland provided a definitive diagnosis in 16/26 (60%). Conclusion : The prevalence of primary Sjogren's syndrome is rare even in tertiary care rheumatology clinics. The clinical and immunological profile as seen here is similar to that reported in Western countries.

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Source:Copyright of this article belongs to Association of Physicians of India.
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Deposited On:27 Jan 2012 13:18
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