Prevalence of subclinical amyloidosis in ankylosing spondylitis

Singh, Gurmeet ; Kumari, Niraj ; Aggarwal, Amita ; Krishnani, Narendra ; Misra, Ramnath (2012) Prevalence of subclinical amyloidosis in ankylosing spondylitis Journal of Rheumatology, 34 (2). pp. 371-373. ISSN 0315-162X

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Objective: To study the prevalence of secondary amyloidosis in Indian patients with ankylosing spondylitis (AS). Methods: Seventy-two AS patients with disease duration of more than 5 years were included in this study over a period of one and a half years. Abdominal subcutaneous fat pad aspiration (ASFA) was performed with a fine needle, and smears were examined for apple-green birefringence under polarized light after Congo red staining. The amyloid deposits were graded from 1+ to 3+ by visual inspection. Clinical and laboratory features of the patients were correlated with the absence or presence of amyloid deposits. Results: Five patients (6.9%) with AS were positive for amyloid on ASFA. All the patients had 1+ deposit and were male. None of the patients had clinical amyloidosis. ASFA positive patients had a trend towards older age, longer disease duration, more limitation of the spinal mobility, and significantly lower hemoglobin levels. Conclusion: We found in our population that subclinical amyloid deposits can be detected in 7% of AS patients with disease duration longer than 5 years. There is a need to follow up patients with positive ASFA tests to check for the development of clinical amyloid.

Item Type:Article
Source:Copyright of this article belongs to Journal of Rheumatology Publishing Company.
ID Code:79478
Deposited On:27 Jan 2012 14:40
Last Modified:16 Jan 2013 08:31

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