Roy, Gouriprasanna ; Nethaji, Munirathinam ; Mugesh, G. (2006) Bioinorganic chemistry of anti-thyroid drugs: an unusual formation of a copper (II) complex Inorganic Chemistry Communications, 9 (6). pp. 571-574. ISSN 1387-7003
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.inoche.2006.02.018
Abstract
We report the first example of a metal complex derived from the selenium analogue of the anti-thyroid drug methimazole (MSeI). The treatment of the diselenide form of Se-methimazole with copper (II) perchlorate leads to an unexpected deselenation reaction resulting in the formation of a novel copper (II) complex (7). Theoretical studies are performed on compounds 5 and 6 to understand the structural changes that take place at the imidazole moiety upon deselenation. In addition, glutathione peroxidase (GPx) behavior and lactoperoxidase (LPO) inhibition activities of complex 7 are described.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Anti-thyroid Drugs; Copper Complex; DFT Calculations; Lactoperoxidase Inhibition Activity; Methimazole; Selenium |
| ID Code: | 79327 |
| Deposited On: | 25 Jan 2012 06:09 |
| Last Modified: | 25 Jan 2012 06:09 |
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