Mishra, Beena ; Priyadarsini, K. I. ; Mohan, Hari ; Mugesh, G. (2006) Horseradish peroxidase inhibition and antioxidant activity of ebselen and related organoselenium compounds Bioorganic & Medicinal Chemistry Letters, 16 (20). pp. 5334-5338. ISSN 0960-894X
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.bmcl.2006.07.085
Abstract
Horseradish peroxidase (HRP) inhibition and glutathione peroxidase (GPx) activities of ebselen and some related derivatives are described. These studies show that ebselen and ebselen ditelluride (EbTe2) with significant antioxidant activity, inhibit the HRP-catalyzed oxidation reactions. In addition, inhibition of lipid peroxidation and singlet oxygen quenching studies were carried out. Although the inhibition of HRP by ebselen is comparable with that of EbTe2, the inhibitory effect on γ-radiation induced lipid peroxidation and the GPx activity of ebselen is found to be much higher than that of EbTe2.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Ebselen; Antioxidant; Selenium; Horseradish Peroxidase; Lipid Peroxidation |
| ID Code: | 79324 |
| Deposited On: | 25 Jan 2012 06:09 |
| Last Modified: | 25 Jan 2012 06:09 |
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