Sreedhara, Alavattam ; Susa, Nobuyuki ; Patwardhan, Anjali ; Rao, Chebrolu P. (1996) One electron reduction of vanadate(V) to oxovanadium(IV) by low-molecular-weight biocomponents like saccharides and ascorbic acid: effect of oxovanadium(IV) complexes on pUC18 DNA and on lipid peroxidation in isolated Rat hepatocytes Biochemical and Biophysical Research Communications, 224 (1). pp. 115-120. ISSN 0006-291X
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1006/bbrc.1996.0993
Abstract
One electron reduction of vanadate(V) to vanadyl(IV) occurs in the presence of biocomponents, such as, saccharides and L-ascorbic acid under physiological conditions. The vanadyl(IV) complexes thus generated have been demonstrated to introduce nicks in pUC18 DNA in the absence or in the presence of hydrogen peroxide and also exhibit lipid peroxidation in isolated rat hepatocytes. Thus the reducing and complexing abilities of these molecules may help in understanding the in vivo reduction and the resultant toxicity to cells incubated with vanadate(V).
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 79118 |
| Deposited On: | 24 Jan 2012 15:21 |
| Last Modified: | 19 Apr 2012 05:42 |
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