Effect of luteinizing hormone releasing hormone analogues on testosterone metabolism in vitro - a study with mature rat ventral prostates

Maitra, A. ; Joseph, R. ; Sheth, A. R. ; Sheth, N. A. ; Joseph, J. (1988) Effect of luteinizing hormone releasing hormone analogues on testosterone metabolism in vitro - a study with mature rat ventral prostates Journal of Biosciences, 13 (2). pp. 105-108. ISSN 0250-5991

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Official URL: http://www.ias.ac.in/j_archive/jbiosci/13/2/JB-Jun...

Related URL: http://dx.doi.org/10.1007/BF02903090

Abstract

The effects of two luteinizing hormone releasing hormone analogues (a superagonist and an antagonist) on the conversion of testosterone to dihydrotestosterone in homogenates prepared from adult rat ventral prostates were studied. At higher doses, the superagonist showed a significant dose-dependent inhibition of the conversion of testosterone to dihydrotestosterone. In comparison, the antagonist showed only a marginally inhibitory trend. The implications of these observed effects vis-a-vis the use of the analogues in the endocrine management of prostatic cancer have been discussed.

Item Type:Article
Source:Copyright of this article belongs to Indian Academy of Sciences.
Keywords:Prostate; LHRH Analogues; Testosterone Metabolism; 5 α-reductase Activity
ID Code:78587
Deposited On:20 Jan 2012 11:36
Last Modified:18 May 2016 21:20

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