Antisera to gonadotropins and placental function in mice

Thakur, A. N. ; Sheth, A. R. ; Purandare, T. V. ; Munshi, S. R. ; Rao, Shanta S. (1975) Antisera to gonadotropins and placental function in mice Journal of Reproduction and Fertility, 43 (2). pp. 221-224. ISSN 0022-4251

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Official URL: http://www.reproduction-online.org/content/43/2/22...

Related URL: http://dx.doi.org/10.1530/jrf.0.0430221

Abstract

The effect of antisera to ovine LH and ovine prolactin was studied on polyamine levels in the mouse placenta. The antisera were administered on Day 11, 12 or 13 of pregnancy and the mice were killed 24 hr later. The polyamines (spermine, spermidine and putrescine) in the placentae were estimated. Polyamine levels were reduced after treatment with anti-LH on any of the 3 days and after treatment with anti-prolactin serum on Days 11 or 12. Only the spermidine content was reduced when anti-prolactin serum was injected on Day 13 of pregnancy. Placental DNA and RNA levels paralleled those observed for polyamine content. The changes in polyamine content and nucleic acid levels indicate that these antisera to LH and prolactin interfere with placental function.

Item Type:Article
Source:Copyright of this article belongs to Society for Reproduction and Fertility.
ID Code:78572
Deposited On:20 Jan 2012 11:30
Last Modified:20 Jan 2012 11:30

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