Planar triazinium cations from VO2+-assisted ring cyclizations: a remarkably efficient thiazole species for nuclear staining, PDT and anaerobic photocleavage of DNA

Prasad, Puja ; Khan, Imran ; Sasmal, Pijus K. ; Koley, Debasis ; Kondaiah, Paturu ; Chakravarty, Akhil R. (2011) Planar triazinium cations from VO2+-assisted ring cyclizations: a remarkably efficient thiazole species for nuclear staining, PDT and anaerobic photocleavage of DNA Chemical Communications, 47 (13). pp. 3954-3956. ISSN 1359-7345

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Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/2011...

Related URL: http://dx.doi.org/10.1039/C0CC05386D

Abstract

Planar triazinium cationic species, from VO2+-assisted cyclization of 1-(2-thiazolylazo)-2-naphthol, shows efficient DNA intercalative binding, visible light-induced anaerobic plasmid DNA photocleavage activity and photocytotoxicity in HeLa and MCF-7 cancer cells by an apoptotic pathway with selective localization of the compound in the nucleus as evidenced from the nuclear staining and confocal imaging.

Item Type:Article
Source:Copyright of this article belongs to Royal Society of Chemistry.
ID Code:78235
Deposited On:18 Jan 2012 10:51
Last Modified:18 Jan 2012 10:55

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