Suppression of steroidogenesis in mice granulosa cells by a synthetic nonapeptide fragment of human seminal plasma inhibin

Hurkadli, K. S. ; Shahid, J. K. ; Nandedkar, T. D. ; Mahale, S. D. ; Iyer, K. S. ; Sheth, A. R. (1991) Suppression of steroidogenesis in mice granulosa cells by a synthetic nonapeptide fragment of human seminal plasma inhibin Indian Journal of Experimental Biology, 29 (10). pp. 897-899. ISSN 0019-5189

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Abstract

A synthetic nonapeptide, which is C-terminal sequence of 94-amino acid of prostatic inhibin peptide was tested for progesterone and estrogen secretion by mouse granulosa cell cultures. Nonapeptide suppressed the progesterone and estrogen synthesis, the magnitude of suppression was highest at 5 ng dose level for progesterone and 50 ng dose level for estradiol. The study suggests that, nonapeptide exerts its effect by impairing the binding of FSH to granulosa cell receptors.

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ID Code:78227
Deposited On:18 Jan 2012 08:16
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