Certain facets of F^- action on collagen protein in Osseous and non-osseous tissues

Abstract

Collagen, a fibrous protein, constitutes the major bulk of the organic matrix of bone and tendon. In order to probe into the defective mineralization process known to occur as a result of fluoride toxicity and fluorosis, the collagenous constituents have been Investigated with reference to 1) Amino acid composition, 2) Collagen content, 3) Collagen biosynthesis, 4) Collagen crosslink precursors and 5) Collagen bound collagenolytic activity.