Enhancement of in vitro release of FSH from rat pituitaries by a synthetic nonapeptide fragment of human seminal plasma inhibin

Hurkadli, K. S. ; Mahale, S. D. ; Iyer, K. S. N. ; Sheth, A. R. (1989) Enhancement of in vitro release of FSH from rat pituitaries by a synthetic nonapeptide fragment of human seminal plasma inhibin Life Sciences, 45 (15). pp. 1357-1363. ISSN 0024-3205

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Official URL: http://www.sciencedirect.com/science/article/pii/0...

Related URL: http://dx.doi.org/10.1016/0024-3205(89)90022-2

Abstract

A synthetic C-terminal nonapeptide fragment of human seminal plasma inhibin preferentially enhances the basal release of FSH from rat pituitaries incubated in vitro, which indicates a direct action of the peptide on the pituitary. However, in the presence of LHRH, both FSH and LH release was increased particularly at higher doses of the nonapeptide. There was no change in prolactin release at 5 and 50 ng/ml but prolactin release was suppressed significantly at 500 ng/ml.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:78094
Deposited On:17 Jan 2012 10:19
Last Modified:17 Jan 2012 10:19

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