Joseph, R. ; Maitra, A. ; Moodbidri, S. B. ; Sheth, A. R. (1987) Effect of inhibin on testosterone metabolism by rat ventral prostate in vitro Systems Biology in Reproductive Medicine, 18 (3). pp. 205-209. ISSN 1939-6368
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Official URL: http://informahealthcare.com/doi/abs/10.3109/01485...
Related URL: http://dx.doi.org/10.3109/01485018708988484
Abstract
Conversion of radiolabeled testosterone to 5 α-dihydrotestosterone (5 α-DHT) was determined in the rat ventral prostate in vitro, and the effect of inhibin on this conversion was demonstrated. The data revealed that the reduction of testosterone to 5 α-DHT was inhibited in a dose-related manner in the presence of inhibin as compared with the basal reduction. The percentage of testosterone reduced per 10-mg tissue also showed a similar trend. The ratio of radioactive counts for DHT and testosterone was also minimum at the highest does of inhibin used. Inhibin can thus modulate the conversion of testosterone to 5 α-DHT in the rat ventral prostate, and therefore can autocrine-paracrine function can be attributed to the prostate.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Informa plc.. |
| Keywords: | Inhibin; Testosterone Metabolism; Prostate; Rat Hormone |
| ID Code: | 77970 |
| Deposited On: | 16 Jan 2012 12:50 |
| Last Modified: | 16 Jan 2012 12:50 |
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