Ultrastructure of monkey (Macaca radiata) spermatozoa: effect of gossypol in vivo

Kalla, N. R. ; Steiner, M. ; Weinbauer, G. ; Rovan, E. ; Foo, J. ; Hurkadli, K. S. ; Sheth, A. R. ; Frick, J. (1986) Ultrastructure of monkey (Macaca radiata) spermatozoa: effect of gossypol in vivo Urological Research, 14 (5). pp. 247-252. ISSN 0300-5623

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Official URL: http://www.springerlink.com/content/x5x485j6822118...

Related URL: http://dx.doi.org/10.1007/BF00256567


The present study examines the ultrastructure of ejaculated spermatoza from bonnet monkey, Macaca radiata under noraml conditions, with gossypol treatment and during recovery from such treatment. Monkeys were fed orally with gossypol acetic acid (GAA) for 3 months (4 mg/monkey/5 days a weak). Semen samples collected by electroejaculation, and the spermatozoa were examined using both light and electron microscopy. The degree of motility was also noted by Kalla et al. [12]. Ejaculated spermatoza were immotile 90 days after GAA treatment, but little evidence for any abnormality in the spermatozoa could be seen by light microscopy. Some ultrastructural changes were observed, but not to the extent previously reported in spermatozoa of Macaca fascicularis [23]. After termination of treatment, semen samples were obtained every 5th day until sperm count and motility recovered to the normal level. After 90 days only a small proportion of spermatozoa showed abnormal structure. We conclude that in a subhuman animal model gossypol induced effects on sperm motility and morphology are reversible.

Item Type:Article
Source:Copyright of this article belongs to Springer.
Keywords:Monkey Spermatozoa; Gossypol Effect; In Vivo Examination; Ultrastructure
ID Code:77957
Deposited On:16 Jan 2012 12:50
Last Modified:16 Jan 2012 12:50

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