Neonatal screening for congenital hypothyroidism in a developing country: problems and strategies

Desai, M. P. ; Colaco, M. P. ; Ajgaonkar, A. R. ; Mahadik, C. V. ; Vas, F. E. ; Rege, C. ; Shirodkar, V. V. ; Bandivdekar, A. ; Sheth, A. R. (1987) Neonatal screening for congenital hypothyroidism in a developing country: problems and strategies Indian Journal of Pediatrics, 54 (4). pp. 571-581. ISSN 0019-5456

Full text not available from this repository.

Official URL:

Related URL:


Neonatal screening in India poses more organisational and socio-economic rather than medical challenges. Based on the pilot study of 450 cord sera, the plan for screening considered cord TSH<30 μU/ml as normal, 30 to 80 as borderline with recall by letters and >80 as indicative of hypothyroid state, with recall by home visits. Of the 17,240 live births only 12,407 cord sera were collected. Envisaging follow-up difficulties, T4 was assayed in cord sera when TSH was>30 μ U/ml. 2.81% (350) babies needed recall. Only 30% of 302 (2.43%) babies with cord TSG 30 to 80 responded, to recall letters and were normal; availability of both cord TSH and T4 helped in excluding hypothyroidism in majority of non-respondents. Forty-eight (0.38%) newborns had TSH>90 μU/ml; 80% of this group and 100% with TSH> 100 μU/ml were traced by home visits. Hypothyroidism was confirmed in 5/48, biochemically and by thyroid scan. All five hypothyroids had cord TSH>300 μU/ml. The incidence in this nonendemic region of India was 1:2481. Thus false elevation of cord TSH 30 to 300 μU/ml was noted in 0.34% with a chance of detecting a hypothyroid 1 in 10 when TSH>80 μU/ml. Screening strategies in a developing country must ensure meticulous clerical assistance, co-operation and education of nurses and parents, precise and cost effective technics and facilities for continued surveilance of detected hypothyroids.

Item Type:Article
Source:Copyright of this article belongs to Dr. K.C. Chaudhuri Foundation.
ID Code:77955
Deposited On:16 Jan 2012 12:50
Last Modified:16 Jan 2012 12:50

Repository Staff Only: item control page