Joshi, Bhakti ; Schmid, Roland ; Altendorf, Karlheinz ; Apte, Shree Kumar (2004) Protein recycling is a major component of post-irradiation recovery in Deinococcus radiodurans strain R1 Biochemical and Biophysical Research Communications, 320 (4). pp. 1112-1117. ISSN 0006-291X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00062...
Related URL: http://dx.doi.org/10.1016/j.bbrc.2004.06.062
Abstract
Exposure to 6 kGy dose of 60Co γ-rays resulted in immediate growth arrest, followed by complete recovery of Deinococcus radiodurans strain R1 cells. Selective degradation and resynthesis of several predicted highly expressed proteins (including major chaperones, key TCA cycle enzymes, and few stress proteins) and several hypothetical proteins marked the lag period, preceding resumption of growth. A major exercise in protein recycling appears to be an integral component of post-irradiation recovery in D. radiodurans and complements the extensive DNA repair, characteristic of this extremely radioresistant bacterium.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Radioresistance; Deinococcus; Proteomics; PHX Proteins; Chaperones; Protein Recycling; Post-Irradiation Recovery |
| ID Code: | 777 |
| Deposited On: | 25 Sep 2010 04:44 |
| Last Modified: | 05 Jan 2011 09:08 |
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