Pyrroloquinoline-quinone: a reactive oxygen species scavenger in bacteria

Misra, Hari S. ; Khairnar, Nivedita P. ; Barik, Atanu ; Priyadarsini, K. Indira ; Mohan, Hari ; Apte, S. (2004) Pyrroloquinoline-quinone: a reactive oxygen species scavenger in bacteria FEBS Letters, 578 (1-2). pp. 26-30. ISSN 0014-5793

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Transgenic Escherichia coli expressing pyrroloquinoline-quinone (PQQ) synthase gene from Deinococcus radiodurans showed superior survival during Rose Bengal induced oxidative stress. Such cells showed significantly low levels of protein carbonylation as compared to non-transgenic control. In vitro, PQQ reacted with reactive oxygen species with rate constants comparable to other well known antioxidants, producing non-reactive molecular products. PQQ also protected plasmid DNA and proteins from the oxidative damage caused by γ-irradiation in solution. The data suggest that radioprotective/oxidative stress protective ability of PQQ in bacteria may be consequent to scavenging of reactive oxygen species per se and induction of other free radical scavenging mechanism.

Item Type:Article
Source:Copyright of this article belongs to Federation of European Biochemical Societies.
Keywords:Pyrroloquinoline-Quinone; Antioxidant; ROS Scavenging; Oxidative Stress; Radioprotection; Deinococcus
ID Code:776
Deposited On:25 Sep 2010 04:45
Last Modified:16 May 2016 11:58

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