Amino acids and peptides: Part XLIII. Structure-activity studies in the bradykinin series: synthesis of analogs modified in position

Chauhan, Virander S. ; Young, Geoffrey T. (1979) Amino acids and peptides: Part XLIII. Structure-activity studies in the bradykinin series: synthesis of analogs modified in position Bioorganic Chemistry, 8 (3). pp. 333-338. ISSN 0045-2068

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Official URL: http://www.sciencedirect.com/science/article/pii/0...

Related URL: http://dx.doi.org/10.1016/0045-2068(79)90060-9

Abstract

β-Alanyl-, acetimidoyl-, and carbamoyl-bradykinin [(IV), (V), and (VI), respectively] have been synthesized by the picolyl ester method. The first two analogs have very low smooth muscle contracting activity, but the carbamoyl derivative is as fully active as bradykinin itself.

Item Type:Article
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ID Code:77504
Deposited On:12 Jan 2012 14:35
Last Modified:12 Jan 2012 14:35

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