Impact of intermittent preventive treatment with sulfadoxine-pyrimethamine on antibody responses to erythrocytic-stage Plasmodium falciparum antigens in infants in Mozambique

Quelhas, Diana ; Puyol, Laura ; Quintó, Llorenç ; Serra-Casas, Elisa ; Nhampossa, Tacilta ; Macete, Eusebio ; Aide, Pedro ; Mayor, Alfredo ; Mandomando, Inacio ; Sanz, Sergi ; Aponte, John J. ; Chauhan, Virander S. ; Chitnis, Chetan E. ; Alonso, Pedro L. ; Menéndez, Clara ; Dobaño, Carlota (2008) Impact of intermittent preventive treatment with sulfadoxine-pyrimethamine on antibody responses to erythrocytic-stage Plasmodium falciparum antigens in infants in Mozambique Clinical and Vaccine Immunology, 15 (8). pp. 1282-1291. ISSN 1556-6811

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Official URL: http://cvi.asm.org/cgi/content/abstract/15/8/1282

Related URL: http://dx.doi.org/10.1128/CVI.00044-08

Abstract

We evaluated the impact of intermittent preventive treatment in infants (IPTi) with sulfadoxine-pyrimethamine (SP), which was given at ages 3, 4, and 9 months through the Expanded Program on Immunization (EPI), on the development of antibody responses to Plasmodium falciparum in Mozambique. Immunoglobulin M (IgM) and IgG subclass antibodies specific to whole asexual parasites and to recombinant MSP-119, AMA-1, and EBA-175 were measured at ages 5, 9, 12, and 24 months for 302 children by immunofluorescence antibody tests and by enzyme-linked immunosorbent assays. Antibody responses did not significantly differ between children receiving IPTi with SP and those receiving a placebo at any time point measured, with the exception of the responses of IgG and IgG1 to AMA-1 and/or MSP-119, which were significantly higher in the SP-treated group than in the placebo group at ages 5, 9, and/or 24 months. IPTi with SP given through the EPI reduces the frequency of malarial illness while allowing the development of naturally acquired antibody responses to P. falciparum antigens.

Item Type:Article
Source:Copyright of this article belongs to American Society for Microbiology.
ID Code:77424
Deposited On:12 Jan 2012 11:38
Last Modified:13 Jul 2012 14:43

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