Phorbol ester tumor promoter affects the mouse epidermal gap junctions

Kalimi, H. Ghulam ; Sirsat, M. Satyavati (1984) Phorbol ester tumor promoter affects the mouse epidermal gap junctions Cancer Letters, 22 (3). pp. 343-350. ISSN 0304-3835

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Official URL: http://www.sciencedirect.com/science/article/pii/0...

Related URL: http://dx.doi.org/10.1016/0304-3835(84)90173-3

Abstract

Gap junctions are known to mediate cell to cell coupling. This study shows that the potent tumor promoter, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), drastically affects the presence of gap junctions between mouse interfollicular epidermal (IFE) cells. In a time course ultrastructural study after a single application of 1 μ g of TPA the gap junctions between the IFE basal cells begin to decrease by 10 h post-exposure, are totally absent between 18 h and 30 h, and start reappearing at 30 h after TPA application. The potent hyperplasiogen, but very weak tumor promoter, mezerein, produces comparable hyperplasia and wide intercellular spaces but the population of gap junctions remains unchanged.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:77378
Deposited On:12 Jan 2012 08:00
Last Modified:12 Jan 2012 08:00

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