Nicotinamide-adenine dinucleotide-glycohydrolase activity in experimental tuberculosis

Gopinathan, K. P. ; Sirsi, M. ; Vaidyanathan, C. S. (1965) Nicotinamide-adenine dinucleotide-glycohydrolase activity in experimental tuberculosis Biochemical Journal, 94 . pp. 446-451. ISSN 0264-6021

Full text not available from this repository.

Official URL:


The specific NAD-glycohydrolase activity is increased 70 and 50% over the normal in lung and liver tissues respectively of tuberculous mice. 2. Concomitant with the increase in the NAD-glycohydrolase activity, the NAD-isonicotinic acid hydrazide-exchange activity also is increased in infection. The isonicotinic acid hydrazide analogue of NAD formed by the lung enzyme from tuberculous mice has been isolated and identified. 3. The increased NAD-glycohydrolase activity in infection has been shown to be of host-tissue origin and not due to the activation of the bacterial enzyme on growth of the organism in vivo. 4. In addition to NAD, NMN and NADP also participate in the exchange reaction with isonicotinic acid hydrazide catalysed by NAD glycohydrolase. The interference of the drug at the nucleotide level of metabolism is therefore suggested.

Item Type:Article
Source:Copyright of this article belongs to Portland Press.
ID Code:77262
Deposited On:10 Jan 2012 14:05
Last Modified:12 Jul 2012 08:33

Repository Staff Only: item control page