Immunomodulation by two potent analogs of met-enkephalin

Bajpai, K. ; Singh, V. K. ; Dhawan, V. C. ; Haq, W. ; Mathur, K. B. ; Agarwal, S. S. (1997) Immunomodulation by two potent analogs of met-enkephalin Immunopharmacology, 35 (3). pp. 213-220. ISSN 0162-3109

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Met-enkephalin (Tyr-Gly-Gly-Phe-Met) and its more stable analogs, Tyr-D-Ala-Gly-MePhe-Met-NHC3H7-iso (1) and Tyr-D-Ala-Gly-MePhe-Gly-NHC3H7-iso (2) significantly enhanced human T-cell proliferation in vitro after 5 days of incubation in the absence of mitogen. The activity was completely inhibited by naloxone, an opioid antagonist. These peptides significantly enhanced human active T-cell rosette (CD2R) also on in vitro treatment. Furthermore, these analogs stimulated interleukin-2 production by human peripheral blood mononuclear cells in vitro which was completely inhibited by naloxone. These observations suggest that human T-cells bear receptors for Met-enkephalin on their surface. Such findings may provide a link between the central nervous system and the immune system.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Enkephalin; Immunomodulator; T-cell Proliferation; Interleukin-2; T-cell Rosette
ID Code:77
Deposited On:16 Sep 2010 10:47
Last Modified:12 May 2011 03:49

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