Cryptosin induces backbone structural changes in cardiac Na+ and K+ dependent adenosinetriphosphatase

Venkateswara, R. R. ; Dipak, D. ; Banning, J. W. ; Vaidyanathan, C. S. (1990) Cryptosin induces backbone structural changes in cardiac Na+ and K+ dependent adenosinetriphosphatase Biochemistry International, 22 (2). pp. 287-294. ISSN 0158-5231

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Official URL: http://www.venkatrao.net/files/2290097.pdf

Abstract

Cryptosin, a new cardenolide, was found to preferentially bind to Na,K-ATPase enzyme (7), which is believed to be the ouabain binding site on cardiac sarcolemmal membrane. CD spectral studies revealed that cryptosin, in the presence of Na+ and Mg++ ions, bind to Na,K-ATPase and induce a dose-dependent change in the backbone structure of cardiac Na,K-ATPase.

Item Type:Article
Source:Copyright of this article belongs to Academic Press Aust.
ID Code:76961
Deposited On:09 Jan 2012 03:55
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