Fetal mortality associated with cleft lip, cleft palate

Dronamraju, K. R. ; Bixler, D. ; Majumder, P. P. (1982) Fetal mortality associated with cleft lip, cleft palate Johns Hopkins Medical Journal, 151 (6). pp. 287-289. ISSN 0021-7263

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Analysis of 1,516 pregnancies in sibships of probands with cleft lip with or without cleft palate [CL(P)], and 774 pregnancies in those of probands with isolated cleft palate (CP) indicated that fetal mortality significantly increases with liability to clefting. These data are compatible with the multifactorial two-threshold model, according to which a lower threshold level of liability results in a cleft formation whereas a higher level of liability causes a fetal death.

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ID Code:76822
Deposited On:07 Jan 2012 06:44
Last Modified:07 Jan 2012 06:44

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