Hypocalcitonemia in Handigodu disease: a spondylo epi (meta) physeal dysplasia

Badadani, Mallikarjun ; Taranath Shetty, K. ; Agarwal, S. S. (2010) Hypocalcitonemia in Handigodu disease: a spondylo epi (meta) physeal dysplasia International Journal of Clinical and Experimental Medicine (IJCEM), 3 (2). pp. 115-121. ISSN 1940-5901

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Handigodu Disease (HD) is a disorder of the osteoarticular system which is highly prevalent in several villages of two districts viz, Shimoga and Chikmaglur of the state of Karnataka, southern India. The scientific name of the disease is Spondylo-epi-(meta) physeal Dysplasia, Autosomal Dominant variety, Handigodu syndrome. The same has been listed in the International Classification of Skeletal Dysplasias. The calcium homeostasis study was lack in HD. The serum calcium, phosphorus, parathyroid hormone and calcitonin levels after overnight fast state, and 24 hour urinary excretion of calcium and phosphorus were quantified. The decreased level of calcitonin associated with decreased serum total calcium and urinary calcium in HD were observed. The levels of parathyroid hormone, serum phosphorus and urinary phosphorus remain unchanged among HD affected. The Vitamin D3 levels also noticed unchanged in HD affected. Since calcitonin has antiresorption effect on bone, the observed low calcitonin in HD may imply reosrption of bone leading to deformity and causes hypocalcaemia and hypocalciuria. The hypocalcitonemia without change in iPTH associated with hypocalcaemia may be a mutation in Vit D receptor (VDR) or may be an epiphenomenon.

Item Type:Article
Source:Copyright of this article belongs to e-Century Publishing Corporation.
Keywords:Calcitonin; Hypocalciuria; Parathyroid Hormone
ID Code:76165
Deposited On:23 Jun 2012 14:10
Last Modified:18 May 2016 19:56

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