Clavel, Caroline ; Canales, Angeles ; Gupta, Garima ; Javier Cañada, F. ; Penadés, Soledad ; Surolia, Avadhesha ; Jiménez-Barbero, Jesús (2007) NMR investigation of the bound conformation of natural and synthetic oligomannosides to banana lectin European Journal of Organic Chemistry, 2007 (10). pp. 1577-1585. ISSN 1434-193X
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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/ejoc.20...
Related URL: http://dx.doi.org/10.1002/ejoc.200600897
Abstract
The conformational behaviour of three mannose-containing oligosaccharides, namely, the α1→3[α1→6] trisaccharide, a heptasaccharide with α1→2, α1→3 and α1→6 linkages and a tetrasaccharide consisting of α1→3 and α1→2 linkages, when bound to banana lectin (BanLec) has been evaluated by trNOE NMR methods and docking calculations. It was found that the molecular recognition event involves a conformational selection process with only one of the conformations present in the free state of the sugar being recognised at the lectin binding site.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons. |
| Keywords: | Mannose Oligosaccharides; NMR Spectroscopy; Molecular Dynamics; Banana Lectin; Molecular Recognition |
| ID Code: | 75560 |
| Deposited On: | 24 Dec 2011 11:46 |
| Last Modified: | 24 Dec 2011 11:46 |
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