Protein transport into the nucleus

Parnaik, Veena K. (1991) Protein transport into the nucleus Current Science, 61 (7). pp. 454-460. ISSN 0011-3891

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The nucleus is partitioned from the cytoplasm in a eukaryotic cell by the double membrane of the nuclear envelope. The envelope is perforated by pores that regulate the nuclear transport of macromolecules. Nuclear proteins, after synthesis in the cytoplasm, must subsequently enter the nucleus. Several studies have established that these proteins contain highly basic nuclear localization signal sequences, which target them through the nuclear pores. Furthermore, recent evidence suggests that nuclear import of proteins critical for embryonic development, cell division and differentiation can be regulated in novel ways.

Item Type:Article
Source:Copyright of this article belongs to Current Science Association.
ID Code:75320
Deposited On:22 Dec 2011 13:05
Last Modified:18 May 2016 19:23

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