Brahmachari, S. K. ; Ramesh, N. ; Das, M. R. ; Parnaik, V. K. (1985) Poly (dG dC) in the Z-form inhibits E. coli DNA polymerase I and AMV DNA polymerase activity Biochemistry International, 11 (3). pp. 281-290. ISSN 0158-5231
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Abstract
The effect of Z-conformation of DNA on its template activity in DNA synthesis reactions in vitro has been studied. Normal poly(dG-dC) in the B-form, brominated and unbrominated in the Z-form have been compared for their template activity in DNA synthesis reactions mediated by AMV DNA polymerase and E. coli DNA polymerase I. The results indicate that poly(dG-dC) in the Z-form is totally inactive as a template for DNA synthesis and further that it is a strong competitive inhibitor of copying of the B-form DNA.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to International Union of Biochemistry and Molecular Biology. |
| ID Code: | 75314 |
| Deposited On: | 22 Dec 2011 13:03 |
| Last Modified: | 13 Jul 2012 13:31 |
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