Effect of cyclosporin A on murine experimental Salmonellosis

Muthukkumar, S. ; Muthukkaruppan, V. (1988) Effect of cyclosporin A on murine experimental Salmonellosis Comparative Immunology, Microbiology and Infectious Diseases, 11 (3-4). pp. 153-161. ISSN 0147-9571

Full text not available from this repository.

Official URL: http://www.sciencedirect.com/science/article/pii/0...

Related URL: http://dx.doi.org/10.1016/0147-9571(88)90032-X


Investigations were undertaken to evaluate the effect of cyclosporin A (CyA) on primary infection of mice with Salmonella typhimurium. Further, its effect on delayed-type hypersensitivity (DTH) and antibody response to porin, an outer membrane protein of S. typhimurium, has been characterized under different CyA regimen. When mice were infected i.p. with 5 * 10(4) live medium virulent organisms, the bacterial growth increased by about 2 log10 in CyA treated mice. CyA administered daily for 2 weeks following immunization with porin caused profound suppression of DTH and both IgM and IgG antibody responses. Given a single dose of CyA 24 h before DTH elicitation, the drug had a marked suppressive effect on DTH, but not on the antibody response to porin. Treatment on days 0-5 following immunization had no effect on the manifestation of the DTH response nor on the anti-porin IgM response whereas an enhanced level of IgG was observed in this group.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Salmonella Typhimurium; Porin; Cyclosporin A; Delayed-type Hypersensitivity; Anti-porin Antibodies
ID Code:75253
Deposited On:22 Dec 2011 04:08
Last Modified:22 Dec 2011 04:08

Repository Staff Only: item control page