Analysis of carrageenan-induced suppression of antibody response

Vijayakumar, R. K. ; Muthukkaruppan, V. R. (1990) Analysis of carrageenan-induced suppression of antibody response Immunology, 70 (2). pp. 181-185. ISSN 0019-2805

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This paper describes the induction of immunosuppression by multiple injections of carrageenan-lambda (cgn) in BALB/c mice. While cgn alone induced non-specific suppression that persisted for up to 25 days, priming with sheep red blood cells (SRBC) of mice within 10 days of cgn treatment prolonged the suppressive state. Also, antigen (SRBC)-specific suppression was observed when these mice were given a secondary challenge 25-30 days afer priming. Thus multiple cgn treatment along with priming SRBC generated non-specific and specific suppressive states which were transferable by Thy-1+ Lyt-2+ splenocytes.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
ID Code:75238
Deposited On:22 Dec 2011 04:09
Last Modified:22 Dec 2011 13:00

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