Protective immunity induced by outer membrane proteins of Salmonella typhimurium in mice

Udhayakumar, V. ; Muthukkaruppan, V. R. (1987) Protective immunity induced by outer membrane proteins of Salmonella typhimurium in mice Infection and Immunity, 55 (3). pp. 816-821. ISSN 0019-9567

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Official URL: http://iai.asm.org/content/55/3/816.short

Abstract

Outer membrane proteins (OMP) extracted from both smooth (C5) and rough (Rb2) strains of Salmonella typhimurium were able to induce protective immunity to salmonellosis. The OMP-induced protection lasted for at least 6 months. The antibody level was estimated by passive hemagglutination. In the C5 OMP-immunized mice, antibodies to both proteins and lipopolysaccharide were detected. On the other hand, in the Rb2 OMP-immunized mice, antiprotein but not antilipopolysaccharide antibodies were detected. Delayed-type hypersensitivity appeared as early as the second week after immunization with OMP and persisted through the fourth week.

Item Type:Article
Source:Copyright of this article belongs to American Society for Microbiology.
ID Code:74389
Deposited On:22 Dec 2011 13:42
Last Modified:22 Dec 2011 13:42

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