Transgenic plants for the production of edible vaccines and antibodies for immunotherapy

Sharma, Arun K. ; Mohanty, Amitabh ; Singh, Yogendra ; Tyagi, Akhilesh K. (1999) Transgenic plants for the production of edible vaccines and antibodies for immunotherapy Current Science, 77 . pp. 524-529. ISSN 0011-3891

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Abstract

Vaccines and antibodies play a key role in healthcare. However, the cost of production and maintaining a chain for vaccine distribution has so far hampered realizing their full potential. Expression of antigens as vaccines, and of antibodies against antigens of pathogens in transgenic plants is a convenient and inexpensive source for these immunotherapeutic molecules. Various antigens and antibodies have already been expressed successfully in plants and have been shown to retain their native functional forms. Edible plant vaccine against diarrhoea, expressed in potato, and antibody against dental caries, expressed in tobacco, is already in pre-clinical human trials. Attempts are being made to express many proteins of immunotherapeutic use at high levels in plants and to use them as bio-reactors of the modern era

Item Type:Article
Source:Copyright of this article belongs to Current Science Association.
ID Code:74280
Deposited On:09 Dec 2011 05:33
Last Modified:18 May 2016 18:45

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