Singh, Y. ; Shirhatti, V. ; Liu, C. T. ; Davies, H. W. ; Krishna, G. (1986) Inhibition of overall protein and RNA synthesis as a mechanism for the tunicamycin induced decrease in cytochrome P-450 in rat hepatocytes Biochemistry International, 13 (2). pp. 213-220. ISSN 0158-5231
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Abstract
In rat hepatocytes maintained in culture, cytochrome P-450 and NADPH cytochrome c reductase activities were decreased by tunicamycin in a dose and time dependent fashion. The effect of tunicamycin was mainly due to inhibition of protein synthesis. Tunicamycin decreased L-[35S] methionine incorporation into many proteins, including a 52 kDa cytochrome P-450 isozyme. Tunicamycin also reduced RNA synthesis. These results indicate that tunicamycin decreased cytochrome P-450 levels in hepatocytes by inhibiting protein and RNA synthesis.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to International Union of Biochemistry and Molecular Biology. |
| ID Code: | 74268 |
| Deposited On: | 10 Dec 2011 09:12 |
| Last Modified: | 10 Dec 2011 09:12 |
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