Mapping human genetic diversity in Asia

Abdulla, Mahmood Ameen ; Ahmed, Ikhlak ; Assawamakin, Anunchai ; Bhak, Jong ; Brahmachari, Samir K. ; Calacal, Gayvelline C. ; Chaurasia, Amit ; Chen, Chien-Hsiun ; Chen, Jieming ; Chen, Yuan-Tsong ; . . . ; Majumder, P. P.; . . . (The HUGO Pan-Asian SNP Consortium) (2009) Mapping human genetic diversity in Asia Science, 326 (5959). pp. 1541-1545. ISSN 0036-8075

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Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.

Item Type:Article
Source:Copyright of this article belongs to American Association for the Advancement of Science.
ID Code:73352
Deposited On:03 Dec 2011 12:17
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