Sudhir, V. Sai ; Baig, R. B. Nasir ; Chandrasekaran, Srinivasan (2008) Facile entry to 4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-α]pyrazin-6-ones from amines and amino acids European Journal of Organic Chemistry, 2008 (14). pp. 2423-2429. ISSN 1434-193X
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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/ejoc.20...
Related URL: http://dx.doi.org/10.1002/ejoc.200800036
Abstract
A practical and high-yielding regioselective synthesis ofseveral enantiopure 4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyrazin-6-ones is described starting from primary amines and α-amino acid derivatives in a three-step reaction sequence by employing a constrained intramolecular "click" reaction as the key step. The method obviates chromatographic purification of products.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons, Inc. |
| Keywords: | Triazoles; Alkynes; Cycloaddition; Nitrogen Heterocycles; Amino Acids |
| ID Code: | 7327 |
| Deposited On: | 25 Oct 2010 11:49 |
| Last Modified: | 01 Feb 2011 09:16 |
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