On the inheritance of abdominal aortic aneurysm

Majumder, P. P. ; St. Jean, P. L. ; Ferrell, R. E. ; Webster, M. W. ; Steed, D. L. (1991) On the inheritance of abdominal aortic aneurysm The American Journal of Human Genetics, 48 (1). pp. 164-170. ISSN 0002-9297

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To determine the mode of inheritance of abdominal aortic aneurysm, data on first-degree relatives of 91 probands were collected. Results of segregation analysis performed on these data are reported. Many models, including nongenetic and genetic models, were compared using likelihood methods. The nongenetic model was rejected; statistically significant evidence in favor of a genetic model was found. Among the many genetic models compared, the most parsimonious genetic model was that susceptibility to abdominal aortic aneurysm is determined by a recessive gene at an autosomal diallelic major locus. A multifactorial component in addition to the major locus does not increase the likelihood of the data significantly.

Item Type:Article
Source:Copyright of this article belongs to American Society of Human Genetics.
ID Code:73268
Deposited On:03 Dec 2011 12:09
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