Statistical mechanics of thermal denaturation of DNA oligomers

Singh, Navin ; Singh, Yashwant (2003) Statistical mechanics of thermal denaturation of DNA oligomers Pramana - Journal of Physics, 61 (2). pp. 345-352. ISSN 0304-4289

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Official URL: http://www.ias.ac.in/pramana/v61/p345/fulltext.pdf

Related URL: http://dx.doi.org/10.1007/BF02708314

Abstract

Double stranded DNA chain is known to have non-trivial elasticity. We study the effect of this elasticity on the denaturation profile of DNA oligomer by constraining one base pair at one end of the oligomer to remain in unstretched (or intact) state. The effect of this constraint on the denaturation profile of the oligomer has been calculated using the Peyrard-Bishop Hamiltonian. The denaturation profile is found to be very different from the free (i.e. without the constraint) oligomer. We have also examined how this constraint affects the denaturation profile of the oligomer having a segment of defect sites located at different parts of the chain.

Item Type:Article
Source:Copyright of this article belongs to Indian Academy of Sciences.
Keywords:DNA; Elasticity; Defect; Denaturation
ID Code:73157
Deposited On:02 Dec 2011 11:03
Last Modified:18 May 2016 18:07

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