Klug, A. ; Jack, A. ; Viswamitra, M.A. ; Kennard, Olga ; Shakked, Z. ; Steitz, T.A. (1979) A hypothesis on a specific sequence-dependent conformation of DNA and its relation to the binding of the lac-repressor protein Journal of Molecular Biology, 131 (4). pp. 669-680. ISSN 0022-2836
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0022-2836(79)90196-7
Abstract
The structure and properties of the double-helical form of the alternating copolymer poly(dA-dT) are considered. Different lines of evidence are interpreted in terms of a structure in which every second phosphate-diester linkage has a conformation different from that of the normal B form. A rationale for this “alternating-B” structure is given which provides an explanation for the effects of chemical modifications of the T residues on the binding of the poly(dA-dT)· poly(dA-dT) to the lac repressor of Escherichia coli.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 72746 |
| Deposited On: | 03 Dec 2011 11:14 |
| Last Modified: | 03 Dec 2011 11:14 |
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