Chandrasekaran, S. ; Nagaraja, S. (2005) Microwave-assisted synthesis and anti-bacterial activity of some 2-amino-6-aryl-4-(2-thienyl)pyrimidines IL Farmaco, 60 (4). pp. 279-282. ISSN 0014-827X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00148...
Related URL: http://dx.doi.org/10.1016/j.farmac.2005.01.012
Abstract
Some novel 2-amino-6-aryl-4-(2-thienyl)pyrimidines were synthesized from 3-aryl-1-thien-2ylprop-2-en-1-ones and guanidine hydrochloride in presence of alkali by conventional heating in alcoholic medium and microwave heating in solvent-free conditions. The compounds were evaluated for in vitro anti-bacterial activity. The anti-bacterial data revealed that compounds 5a-e had better activity against tested Gram-positive organisms than the reference ciprofloxacin and norfloxacin. However, the compounds were nearly inactive against Gram-negative bacteria. Compounds 5c and e were the most active compounds against Gram-positive bacteria.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Microwave; 2-thienylpropen-2-ones; 2-aminopyrimidines; Anti-bacterial Activity |
| ID Code: | 7219 |
| Deposited On: | 25 Oct 2010 12:08 |
| Last Modified: | 28 May 2011 10:09 |
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