Update on zona pellucida glycoproteins based contraceptive vaccine

Gupta, S. K. ; Srivastava, Neelu ; Choudhury, Sangeeta ; Rath, Archana ; Sivapurapu, Neela ; Gahlay, G. K. ; Batra, Deepika (2004) Update on zona pellucida glycoproteins based contraceptive vaccine Journal of Reproductive Immunology, 62 (1-2). pp. 79-89. ISSN 0165-0378

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.jri.2003.08.004


Zona pellucida (ZP) glycoproteins, due to their critical role in mammalian fertilization, have been proposed as candidate immunogens for development of a contraceptive vaccine. Active immunization studies in a variety of animal species, employing either native or recombinant zona proteins, has established their contraceptive potential. Hence, ZP glycoprotein-based contraceptive vaccines have a very good potential for controlling wild life population. To make it a realistic proposition, additional research inputs are required to develop new potent adjuvants and novel practical strategies for vaccine delivery. The observed ovarian dysfunction, often associated with immunization by ZP glycoproteins, is one of the major obstacles for their application in the control of human population. Ongoing studies to delineate epitopes of ZP glycoproteins that will generate an immune response capable of inhibiting fertility without any untoward effects on ovarian functions will help in determining their feasibility for human use.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Zona Pellucida Glycoproteins; Contraceptive Vaccine; Recombinant Proteins; Synthetic Peptides; DNA Vaccine; Adjuvants; Ovary
ID Code:72133
Deposited On:28 Nov 2011 06:20
Last Modified:28 Nov 2011 06:20

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