Yoon, Taeyoung ; De Lombaert, Stephane ; Brodbeck, Robbin ; Gulianello, Michael ; Chandrasekhar, Jayaraman ; Horvath, Raymond F. ; Ge, Ping ; Kershaw, Mark T. ; Krause, James E. ; Kehne, John ; Hoffman, Diane ; Doller, Dario ; Hodgetts, Kevin J. (2008) The design, synthesis and structure-activity relationships of 1-aryl-4-aminoalkylisoquinolines: a novel series of CRF-1 receptor antagonists Bioorganic & Medicinal Chemistry Letters, 18 (3). pp. 891-896. ISSN 0960-894X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S09608...
Related URL: http://dx.doi.org/10.1016/j.bmcl.2007.12.050
Abstract
The design, synthesis and structure-activity relationships of a novel series of CRF-1 receptor antagonist, the 1-aryl-4-alkylaminoisoquinolines, is described. The effects of substitution on the aromatic ring, the amino group and the isoquinoline core on CRF-1 receptor binding were investigated.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | CRF-1 Receptor Antagonist; 1-aryl-4-aminoalkylisoquinoline; Depression; Anxiety |
| ID Code: | 7172 |
| Deposited On: | 25 Oct 2010 12:24 |
| Last Modified: | 04 Feb 2011 05:05 |
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