Prevention of the effects of vitamin A palmitate on tail regeneration in Bufo tadpoles by sulphadiazine

Abstract

In Bufo melanostictus tadpoles treated with vitamin A palmitate after tail amputation, regeneration of notochord, spinal cord and muscles was inhibited, and the regenerating caudal fin formed an abnormal pouch. Sulphadiazine given together with vitamin A prevented the influence of the latter resulting in normal tail regeneration in many cases. This effect of sulphadiazine was subject to its amount relative to that of vitamin A used.