Harikumar, K. G. ; Chattopadhyay, Amitabha (1998) Modulation of agonist and antagonist interactions in serotonin receptors by alcohols FEBS Letters, 438 (1-2). pp. 96-100. ISSN 0014-5793
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00145...
Related URL: http://dx.doi.org/10.1016/S0014-5793(98)01284-8
Abstract
The serotonin type 1A (5-HT1A) receptors are members of a superfamily of seven transmembrane domain receptors that couple to GTP binding regulatory proteins (G-proteins). Serotonergic signalling has been shown to play an important role in alcohol tolerance and dependence. We have studied the effects of alcohols on ligand (agonist and antagonist) binding to bovine hippocampal 5-HT1A receptor in native as well as solubilized membranes. Our results show that alcohols inhibit the specific binding of the agonist OH-DPAT and the antagonist p-MPPF to 5-HT1A receptors in a concentration-dependent manner.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Federation of European Biochemical Societies. |
| Keywords: | Alcohol; Serotonin receptor; 8-hydroxy-2-(di-n-propylamino)tetralin; 4-(2'-methoxy)-phenyl-1-[2'-(n-2"-pyridinyl)-p-iodobenzamido]ethyl-piperazine; 4-(2'-methoxy)-phenyl-1-[2'-(n-2"-pyridinyl)-p-fluorobenzamido]ethyl-piperazine; Bovine Hippocampus |
| ID Code: | 7136 |
| Deposited On: | 25 Oct 2010 12:30 |
| Last Modified: | 16 May 2016 17:23 |
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