Wyllie, Susan ; Mandal, Goutam ; Singh, Neeloo ; Sundar, Shyam ; Fairlamb, Alan H. ; Chatterjee, Mitali (2010) Elevated levels of tryparedoxin peroxidase in antimony unresponsive Leishmania donovani field isolates Molecular and Biochemical Parasitology, 173 (2). pp. 162-164. ISSN 0166-6851
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.molbiopara.2010.05.015
Abstract
Enhancement of the anti-oxidant metabolism of Leishmania parasites, dependent upon the unique dithiol trypanothione, has been implicated in laboratory-generated antimony resistance. Here, the role of the trypanothione-dependent anti-oxidant pathway is studied in antimony-resistant clinical isolates. Elevated levels of tryparedoxin and tryparedoxin peroxidase, key enzymes in hydroperoxide detoxification, were observed in antimonial resistant parasites resulting in an increased metabolism of peroxides. These data suggest that enhanced anti-oxidant defences may play a significant role in clinical resistance to antimonials.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Antimonial resistance; Leishmania donovani; Tryparedoxin peroxidase |
| ID Code: | 71350 |
| Deposited On: | 25 Nov 2011 07:42 |
| Last Modified: | 25 Nov 2011 07:42 |
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