Effect of treatment with Interferon-γ alone in visceral leishmaniasis

Sundar, Shyam ; Murray, Henry W. (1995) Effect of treatment with Interferon-γ alone in visceral leishmaniasis Journal of Infectious Diseases, 172 (6). pp. 1627-1629. ISSN 0022-1899

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Official URL: http://jid.oxfordjournals.org/content/172/6/1627.a...

Related URL: http://dx.doi.org/10.1093/infdis/172.6.1627


Interferon-γ (IFN-γ) enhances the therapeutic response to pentavalent antimony in patients with visceral leishmaniasis. To determine the effect of cytokine immunotherapy alone, 9 patients with kala-azar were treated with IFN-γ before receiving antimony. After 20 days of IFN-γ therapy, 4 patients showed no parasitologic response; in the remaining 5 patients, however, splenic aspirate parasite scores declined from 4.2 ±: 0.2 to 1.2 ±: 0.5 (mean ±: SE). These results indicate that treatment with IFN-γ alone can induce visceral antileishmanial activity. However, the limited efficacy in this uncontrolled pilot trial suggests that the therapeutic role of IFN-γ in kala-azar is that of an adjunct to conventional antimony treatment.

Item Type:Article
Source:Copyright of this article belongs to University of Chicago Press.
ID Code:71290
Deposited On:25 Nov 2011 07:00
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